Scaling-Up Signaling Pathway Analysis

Scaling up software architecture analysis

This paper will show how architecture design and analysis techniques rest on a small number of foundational principles. We will show how those principles have been instantiated as a core set of techniques. These techniques, combined together, have resulted in several highly successful architecture analysis and design methods. Finally, we will show how these foundations, and the techniques that ...

P18: Signaling Pathway in Long-Term Potentiation

Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...

A signaling pathway AKTing up in schizophrenia.

The serine/threonine protein kinase AKT (also known as PKB) signaling pathway has been associated with several human diseases, including schizophrenia. Studies in preclinical models have demonstrated that impaired AKT signaling affects neuronal connectivity and neuromodulation and have identified AKT as a key signaling intermediary downstream of dopamine (DA) receptor 2 (DRD2), the best-establi...

colorectal cancer and nf-?b signaling pathway

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

Scaling Up